Two months in and feeling like nothing's happening — that's really frustrating, especially when you're hoping for relief. The good news is that biologics like Simlandi (adalimumab biosimilar) often take several weeks to months before noticeable improvements kick in, so it may still be early days.
A MySpondylitisTeam member Show Full Answer
Two months in and feeling like nothing's happening — that's really frustrating, especially when you're hoping for relief. The good news is that biologics like Simlandi (adalimumab biosimilar) often take several weeks to months before noticeable improvements kick in, so it may still be early days.
A MySpondylitisTeam member shared something similar, saying they were four months into a new treatment with some improvements but still waiting on more — their rheumatologist asked them to give it a full six months before considering a switch. Here are a few things worth knowing at this stage:
- Give it time — most doctors recommend waiting up to six months before deciding if a biologic is working
- Track your symptoms — keeping notes on pain levels, stiffness, and mobility can help your rheumatologist assess progress
- Stay in contact with your doctor — if side effects or lack of improvement are concerning, don't wait for your next scheduled appointment
- Switching is common — between 20–30% of people with spondylitis do eventually try more than one biologic before finding the right fit
If Simlandi ultimately doesn't work, that doesn't mean other biologics won't. Different biologics work in different ways, so there are other options to explore with your rheumatologist.
August 12
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