I am also on methotrexate and prednisone 5mg....lately my lower back, lumbar feels like stabbing knives. Terrible pain. I'm not aware of any meds to help other than the strong stuff which you have tried. I only use extra strength Tylenol. Wish there were a remedy for this killer!!! 😥😥😥

My mother went through years of pain and shots ..i will not do shots..I use 3 ibuprofen and 2 RAPID RELEASE TYLENOL..I do use voltaren creme and I'm allergic to prednisone steroids ..😘.I will not take opioids as I am a recovering addict however I do have break through of pain but I can and do function with 2 active teenagers ..it's not easy but I'm not going to let this disease own me....and yes definately invest in a mattress rest is very important

I don't know how anyone can get pain relief from Tylenol. Its not an anti inflammatory med. My son who has our problem takes 2 Advil with 2 Tylenol every four hours and one muscle relaxer, Tizinidin. He still has some discomfort but the pain isn't unbearable.