Overview
Methotrexate is a prescription drug approved by the Food and Drug Administration (FDA) to treat severe cases of psoriasis, rheumatoid arthritis, and some types of cancer. Methotrexate is sometimes prescribed to treat spondylitis. Methotrexate is sold under the brand names Rheumatrex and Trexall.

Methotrexate is an immunomodulator, or drug that modifies the immune system. Methotrexate is a type of disease-modifying antirheumatic drug (DMARD). Methotrexate is believed to suppress the immune system in several ways, reducing the activity of T cells, B cells, interleukins, and enzymes that play a role in autoimmune attacks.

How do I take it?... read more

Methotrexate is generally prescribed to be taken once or twice each week.

Methotrexate may be taken orally or by intramuscular or intravenous injection.

Side effects
The FDA-approved label for Methotrexate lists common side effects including nausea, vomiting, loss of appetite, and temporary hair loss.

Rare but serious side effects listed for Methotrexate include infections, birth defects, seizures, and damage to liver, lungs, or kidneys.

For answers to frequently asked questions about exposure to Methotrexate during pregnancy and breastfeeding, visit the experts at MothertoBaby.org.

For more details about this treatment, visit:

Methotrexate – Drugs.com
https://www.drugs.com/methotrexate.html

Medications Used to Treat Ankylosing Spondylitis and Related Diseases – Spondylitis Association of America
http://www.spondylitis.org/Medications

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