I tried 5 Biologics before throwing in the towel due to none of them helping my pain. My once perfect blood test results started revealing succumbing to those side affects you are concerned about. Liver, kidneys, blood cell production and more. The good news is that you can recover relatively quickly and completely from the side affects of medications when you catch those side affects early on. Keep a close watch on all your blood tests. You dont want to just be in the green zones of all those readings, you want to be dead in the middle of the green zones. "Acceptable" readings are based on the averages of the population, but the average in the population of modern humanity is sick sick sick. Don't take medication you dont thoroughly understand how it works and how it's made. Now i don't take any biologics or DMARDS. An occasional tylenol for arthritis, less often a prescription meloxicam, rarely prednisone. Doing better now than ever. Because you are seeking good news on your med i will just defer you to my prior posts on medication vs alternative treatments and the details of much research i did on that topic the past couple of years. Check under the updates tab and treatments tabs on my wall for those. In summary, if you can find a functional medicine dr to guide you to the causes and then resolutions of the causes for your disease you will be far better off than just trial and error of modern medication pushed through the Rheumatology network. Reach out for further details anytime. Yours in better health P 😌🙏