I was diagnosed with Ankylosing spondylitis hbla27 and Crohn’s disease. I am currently on cosentyx, which is helping with some pain. I’ve tried simponi which I had to many side effects. Inflectra was the next biologic and it caused rashes, tightness in my chest (couldn’t take a deep breath. Also methotrexate and sulfasalazine which caused me to bleed internally where I was passing blood in my stool.
Every medication has a different effect on people. Basically your a science project until they find the right medication your body will accept and not reject.
Best of luck to you…

Careful with the methotrexate I had a lot of side effects

Ive been on humira for about 8 months now. I was worried about the biologic too, but i've had 0 side effects and no sickness since starting. If I had to give it a number on how helpful I think it is
My mornings suck no matter what, but I think this helps make it manageable. I don't know though, there isn't much relief.

I'm about to start methotrexate (chemo drug) to help the effectiveness of the humira.

good luck!

I wa just diagnosed with AS and I'm afraid of the biologic medication because I don't know what could happen with the side affects or if it will work or make the pain worse

I’m in the same boat. I am on my second biologic because my first one, Remicade, caused a reaction after my 4th infusion. The Remicade did help with my stiffness.
Now I’m on Cosentyx and not feeling much. Stiffness is terrible and the pain is horrible.
Frustrating!