My brother has had both of his knees, sacroileac joints and his shoulders injected with the new synovial fluid replenishment injections. He say his doctor really knows his stuff. My brother had spinal fusion by age 40 due to degenerative disk, degenerative joint and spinal stenosis. His blood test for HLA-B27 came back okay. How can he be this eat up with arthritis for years, and have inflammatory ulcerative colitis and not have enteropathic or ankylosing spondylitis?