I have been on this medication (this one is a self injecting pen) since October. I really do think each medication has worked. Last summer/early fall was rough for me... lots of pain and extreme fatigue. But I have been doing much better since starting this new one. This has happened to me with each medication. Hopefully this one works for a longer period of time. I will take any relief I can get, for as long as I can get it. I haven't been on any prescription pain killers... just my biologic and OTC meds (like ibuprofen). I also take a few supplements... a morning probiotic (for gut health), a Vitamin D with lunch, and curcumin. I may start a few others soon, as I believe these really help keep my inflammation down. I also go to a physical therapist once a week. I believe she is helping me with mobility, posture and flexibility. Most days I seem to be able to function just fine. I do not work outside of the home, which helps me manage the bad days. I mostly just manage our home - cooking, cleaning, etc. We live in south Florida so we get a lot of friends and family visiting in the winter months. Sometimes I feel like I am running a bed and breakfast. But I also love having people around - it helps me stay positive and active. And, quite often our guests treat us to dinner out, which is really nice. When they leave, I rest for a day or two.