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A MySpondylitisTeam Member asked a question 💭
Alabama

55 year old male, hlab27 positive, symptoms last few years. Anyone else diagnosed with this

March 2
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A MySpondylitisTeam Member

@A MySpondylitisTeam Member. It's important to understand that AS, and all autoimmune conditions, are the result of an accumulation of assaults on the body from multiple sources. The labs and imaging will change over time as a result of everything from continued exposure to toxins, bacteria, etc as well as aging body being used normally. Genetics is NOT a cause, its just a predisposition, and many people with AS and other autoimmune conditions do not have genetics as a contributing factor. Furthermore, no medication, including the new age Biologics will address the problem. The only way to effectively address it is to get deep dive tests to reveal the imbalances in your body causing the symptoms. The real problem is that your regular drs, even Specialists like Rheumatologists, will not likely order the types of tests needed because they are not insurance industry standard of care protocols, even though they should be. It's all about profits, including the (ineffective) medications typically prescribed. Yep, a real problem. To get to disease resolution and keep it from getting severe enough to show up on images (you're lucky so far), you will need to either order the tests yourself from a lab, or find a Functional Medicine practitioner who will order them. After the causes in your body are revealed - could be HPylori, streptococcus, klebsiella, mold myxotoxins, heavy metals, lyme and other parasites, etc, etc. - then specific protocols can be used with primarily nutrient sources to remove the problems from your body and set the nutritional balances straight. Only then can you begin to feel better and stop the progression of disease. It's long and complicated, but absolutely CAN be done and your vitality restored. Yours in better health P ☺️ 🙏

March 2
A MySpondylitisTeam Member

MRI and x-ray of SI joints were clear. No inflammation markers, negative ana. Believe inflammation is in lumbar or thoracic

March 2
MySpondylitisTeam

What are experiences with late-onset non-radiographic axial spondyloarthritis when HLA-B27 positive?

Getting a diagnosis of non-radiographic axial spondyloarthritis (nr-axSpA) can be challenging, especially with late onset. Since damage isn't visible on X-rays yet, doctors rely on a combination of your symptoms, blood Show Full Answer

What are experiences with late-onset non-radiographic axial spondyloarthritis when HLA-B27 positive?

Getting a diagnosis of non-radiographic axial spondyloarthritis (nr-axSpA) can be challenging, especially with late onset. Since damage isn't visible on X-rays yet, doctors rely on a combination of your symptoms, blood tests like HLA-B27, and MRI scans to make the diagnosis.

Being HLA-B27 positive supports your diagnosis. About 80-90% of people with axial spondyloarthritis test positive for this gene. People who are HLA-B27 positive tend to develop symptoms earlier and may have more family history of the condition, though late onset certainly occurs.

Women with axial spondyloarthritis often show less damage on imaging tests, which can make diagnosis more difficult and potentially delayed. The hallmark symptom doctors look for is sacroiliitis - inflammation where your lower spine connects to your pelvis.

Your diagnosis is based on clinical judgment combining:
- Inflammatory back pain symptoms
- Positive HLA-B27 test
- Evidence of inflammation on MRI (even if X-rays are clear)
- Elevated inflammation markers like CRP or ESR (though not everyone has these)

The non-radiographic form means you're catching it before significant structural damage occurs, which is actually beneficial for treatment outcomes.

March 2

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