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Hi. I have a question that I keep getting the run around from my doctors about. Diff btwn HLA-B27 ANTIGEN vs genotype.

A MySpondylitisTeam Member asked a question 💭
Grass Lake, MI

I tested pos for the antigen, so then my doc ordered the genotypes test which was neg. Mind you I have a LOT of the symptoms of AS though imaging hasn't shown "spondylitis" per se (spondylosis, facets which are evidence of bone problems). So, o keep getting told I don't have it, now based on the negative genotyping. No matter that my daily life is a struggle. That I'm on daily prednisone which is the only thing helping me get out of bed but my doc wants me to go off of it (which, I… read more

November 9, 2024
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MySpondylitisTeam

It sounds like you're dealing with a lot, and it's important to find a rheumatologist who understands the nuances of your condition. Here are some key points based on my knowledge base:

- HLA-B27 Antigen vs. Genotype: Testing positive for the HLA-B27 antigen means you have a protein on your white blood cells that is Show Full Answer

It sounds like you're dealing with a lot, and it's important to find a rheumatologist who understands the nuances of your condition. Here are some key points based on my knowledge base:

- HLA-B27 Antigen vs. Genotype: Testing positive for the HLA-B27 antigen means you have a protein on your white blood cells that is associated with certain autoimmune conditions, including ankylosing spondylitis (AS). However, not everyone with AS has the HLA-B27 antigen, and not everyone with the antigen develops AS. Genotyping can provide more detailed genetic information, but a negative result doesn't rule out AS.

- Nonradiographic Axial Spondyloarthritis (nr-axSpA): This form of spondylitis doesn't show up on X-rays but can still cause significant symptoms. MRI and other imaging techniques, along with blood tests, are often used to diagnose nr-axSpA.

- Finding a Rheumatologist: It's crucial to find a rheumatologist who is experienced with both radiographic and nonradiographic forms of spondylitis. The American College of Rheumatology's website or local support groups might have recommendations for specialists in Southeast Michigan.

- Treatment: While prednisone can help manage symptoms, long-term use has risks. Discuss alternative treatments with your rheumatologist, such as biologics or other disease-modifying antirheumatic drugs (DMARDs).

Your daily struggle is valid, and finding the right care is essential. Keep advocating for yourself and seeking a specialist who understands your condition.

November 9, 2024

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