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Real members of MySpondylitisTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Has Anyone Had Severe Mood Changes Or Sensitivity With Methotrexate?

A MySpondylitisTeam Member asked a question 💭
Gaylord, MI

Depression is well controlled with anti-depressants and mood stabilizers until I started meds.

July 31, 2024
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A MySpondylitisTeam Member

Thank you for letting me know. I do need to get my bloodwork done before my next appt, sounds like I should do it sooner rather than later. Glad you’re feeling better!

August 1, 2024
A MySpondylitisTeam Member

@A MySpondylitisTeam Member
I stopped Methotrexate in January due to the impact on kidney’s and liver function.
I really felt myself again once I stopped. I was very tearful for 24-48 hours after the injection and it definitely had an impact on my mental health/energy levels.
Patients react differently to medications, but methotrexate definitely did not suit me!
Sending hugs and support

July 31, 2024
A MySpondylitisTeam Member

@A MySpondylitisTeam Member
From my experience, I would definitely keep an eye on your bloods and check in with your GP/PCP.
All the best of luck and feel free to reach me with anything

August 2, 2024
A MySpondylitisTeam Member

Methotrexate, used for treating spondylitis, has a range of side effects. Common side effects include:

- Nausea
- Vomiting
- Loss of appetite
- Temporary hair loss

Rare but serious side effects include:

- Infections
- Birth defects
- Seizures
- Damage to liver, lungs, or kidneys

Severe mood changes or sensitivity are Show Full Answer

Methotrexate, used for treating spondylitis, has a range of side effects. Common side effects include:

- Nausea
- Vomiting
- Loss of appetite
- Temporary hair loss

Rare but serious side effects include:

- Infections
- Birth defects
- Seizures
- Damage to liver, lungs, or kidneys

Severe mood changes or sensitivity are not specifically listed among the common or rare side effects in the provided knowledge base. If you experience unexpected side effects, it's important to consult your doctor.

July 31, 2024

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