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Real members of MySpondylitisTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Has anyone had issues with Enbrel? Started about 2 months ago and everything was ok, now I am so nauseous and pain levels are ridiculous!

A MySpondylitisTeam Member asked a question 💭
Boone, NC

I switched from Simponi Aria and chose Enbrel over Inflectra but wondering if I just do better with infusions. All opinions and advice is welcome.

June 14, 2024
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Reactions
A MySpondylitisTeam Member

I have read, and my rheumatologist told me that these meds don’t work for everyone, but there are many out there. They can change yours. I got lucky with Humira, but have been told, that if it stops working, they would try another. Some may work for a while and stop.

June 15, 2024
A MySpondylitisTeam Member

Thanks. I have disc protrusion too so I don’t know what’s going on but after my injection Wednesday the pain and nausea have just got progressively worse.

June 15, 2024
A MySpondylitisTeam Member

Hi Brandy so sorry to hear that the Enbrel is not working. I not sure if I had mentioned to you that I was Simponi it worked good but then stopped. They switched me to Cimiza injections it is really helping

June 15, 2024
MySpondylitisTeam

I'm sorry to hear you're experiencing these issues. Enbrel (Etanercept) can have side effects. Common ones include:

- Infections
- Injection site reactions

Rare but serious side effects include:

- Congestive heart failure
- Lupus-like syndrome
- Demyelinating diseases (e.g., multiple sclerosis)
- Blood cell disorders
- Show Full Answer

I'm sorry to hear you're experiencing these issues. Enbrel (Etanercept) can have side effects. Common ones include:

- Infections
- Injection site reactions

Rare but serious side effects include:

- Congestive heart failure
- Lupus-like syndrome
- Demyelinating diseases (e.g., multiple sclerosis)
- Blood cell disorders
- Severe allergic reactions or infections
- Increased risk of certain cancers (e.g., lymphoma)

If you're experiencing severe nausea and increased pain, it's important to contact your healthcare provider immediately. They can help determine if these symptoms are related to Enbrel and discuss potential adjustments to your treatment.

June 14, 2024

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