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HLAB27 Positive But Not Inflammation Markers??

HLAB27 Positive But Not Inflammation Markers??

Question...I saw this asked 2 years ago by someone but didn't see many answers. My inflammation markers are negative and HLAB27 is +. I have (in 4 years) developed severe joint facet arthropathy in my lumbar spine and also have SI degeneration. I know this has all happened in 4 years because in 2018 my MRI lumbar was as close to normal as you can get. I have severe stiffness in lower back, following 3 and a half decades of hyper mobility. I have had 2 cervical discetomies as well. I'm having SI… read more

A MySpondylitisTeam Member said:

Courtney, I also had fairly low inflammation markers and HLAB-27+. Are you taking any medications/supplements? I was taking Apriso for ulcerative colitis so I believe that lowered my levels. Also, I take Krill Oil and Turmeric. What about NSAIDs or steroids? If you are taking those it will lower your blood inflammation levels because that is their job. However, once the inflammation has done damage, it could be in a quieter period, but still causing the joint pain. The SI injections are very helpful and if they work after a couple times then you might be able to get the pain management doctor to diagnosis you with sacroiliitis. However, you should have already been diagnosed based on your MRI. One Rheumatologist told me that I had just degenerative arthritis, but the other doctor finally diagnosed me after a year. I mentioned to him the ASAS Criteria for Rheumatologists. We tried Plaquenil unsuccessfully and diagnosis went from inflammatory polyarthropathy w/ fibromyalgia to axial spondylarthritis with fibromyalgia and now treatment with Sulfasalazine. I am noticing a small reduction in pain and it's only been a month on the Sulfasalazine.

posted 27 days ago
A MySpondylitisTeam Member said:

Oh good, I hope it can help you! Your MRI radiology report should be enough, that is what my Rheumatologist had asked for. He didn't even want to see the actual disc of images. I am not certain if taking IBprofen the day of would effect the test, but if that is what you use on a regular basis for pain then I believe it could appear you don't have inflammation, but really there is an underlying rheumatological condition going on. In fact, IB profen is one of the first treatments they recommend to stop the joint damaging inflammation. However, I had to stop the NSAIDs because of bleeding with bowel movements and flaring of my ulcerative colitis with bloating and constipation. Fun stuff.lol Anyhow, maybe this will give you a good arguing point, if the doctor tries to dismiss your concerns.

posted 24 days ago
A MySpondylitisTeam Member said:

This is super helpful. I had taken an 800 MG ibuprofen about 1 hour before the appointment and labs. I only had a sacral MRI but not an xray.

posted 26 days ago
A MySpondylitisTeam Member said:

Gotcha. Mine are usually higher than normal, but have been for a while. I hope you do get a diagnosis. I know that it is hard without one. Have you had an x-ray of your hips done?

posted 27 days ago
A MySpondylitisTeam Member said:

I mean the sedimentary and c-reactive protein were negative. The labs that show inflammation. I don't see rheumatologist until July 12. I am sorry for all you have gone through. I am hoping to get a diagnosis and get some sort of treatment started so the rate of this progression can slow down, but have this fear that Doctors will blow me off and not see that there is something treatable happening:/

posted 27 days ago
What is Causing Your Inflammation? Read more >
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