Connect with others who understand.

sign up Log in
About MySpondylitisTeam
Powered By

Trexall is a prescription drug approved by the Food and Drug Administration (FDA) to treat severe cases of psoriasis, rheumatoid arthritis, and some types of cancer. Trexall is also referred to by its drug name, Methotrexate. Methotrexate is sometimes prescribed off-label to treat spondylitis. Methotrexate is sometimes prescribed off-label to treat spondylitis. A 2013 review concluded that there is not enough evidence that Methotrexate provides benefits for people with spondylitis. Methotrexate does not improve symptoms in cases of axial spondyloarthritis (axSpA) and is not recommended. However, combining Methotrexate and Adalimumab (Humira) has been associated with long-term maintenance in axSpA.

Trexall is an immunomodulator, or drug that modifies the immune system. Trexall is a type of disease-modifying antirheumatic drug (DMARD). Trexall is believed to suppress the immune system in several ways, reducing the activity of T cells, B cells, interleukins, and enzymes that play a role in autoimmune attacks.

How do I take it?
Trexall is generally prescribed to be taken once or twice each week.

Trexall comes in tablet form.

Side effects
The FDA-approved label for Trexall lists common side effects including dizziness, malaise, fatigue, chills, fever, nausea, abdominal pain, infections, mouth sores, and leukopenia (decreased white blood cells).

Rare but serious side effects listed for Trexall include toxic reactions, severe infections and blood disorders, birth defects, seizures, and damage to liver, lungs, or kidneys.

For answers to frequently asked questions about exposure to Methotrexate during pregnancy and breastfeeding, visit the experts at

For more details about this treatment, visit:

Trexall – RxList

Medications Used to Treat Ankylosing Spondylitis and Related Diseases – Spondylitis Association of America

Methotrexate for ankylosing spondylitis - Cochrane Database of Systematic Reviews

Methotrexate Lowers Immunogenicity to Adalimumab in Axial Spondyloarthritis - Rheumatology Network

Continue with Facebook
Continue with Google
Lock Icon Your privacy is our priority. By continuing, you accept our Terms of use, and our Health Data and Privacy policies.
Already a Member? Log in