Formulations of orphenadrine citrate, aspirin, and caffeine are available as prescription medications approved by the U.S. Food and Drug Administration (FDA) to treat acute musculoskeletal pain in addition to rest and physical therapy. Currently available brands in the U.S. include Orphengesic. The brands Invagesic and Norgesic were previously available but have since been discontinued.
Orphenadrine citrate is a muscle relaxant. Aspirin is a nonsteroidal anti-inflammatory drug (NSAID). Caffeine is a stimulant believed to improve the effectiveness of the other active ingredients.
How do I take it?
Dosing of this medication will vary from person to person. It is usually taken three to four times per day. People taking orphenadrine citrate/aspirin/caffeine should follow prescribing information provided by the doctor and/or listed on the label.
Orphenadrine citrate/aspirin/caffeine comes in tablet form.
Common side effects include headache, drowsiness, blurred vision, weakness, dry mouth, nausea, vomiting, trouble urinating, fast heartbeat, or heart palpitations.
Rare but serious side effects include hallucinations, birth defects, syncope (fainting), and gastrointestinal bleeding.
For more details about this treatment, visit:
Orphenadrine — MedlinePlus
Orphenadrine, Aspirin, and Caffeine (Oral Route) — Mayo Clinic